• TuVivo-ProAge: Age-controlled prostate-cancer mouse model

Precise PTEN knockout at young, middle-aged, or aged stages reproduces human-relevant progression from PIN to adenocarcinoma and reveals age-specific drug-response and inflammatory signatures

• TuVivo-TNBC: Triple negative breast cancer patient-derived xenografts

12 genetically and socio-demographically diverse PDXs from New Orleans patients capture the heterogeneity and health-disparity factors of triple-negative breast cancer, enabling realistic efficacy, resistance, and biomarker studies

• TuVivo-Meno: Mouse model of perimenopause and menopause

Chemically induces gradual, human-like hormonal decline without ovariectomy, preserving androgen production and allowing temporal control of perimenopause; validated across metabolic, inflammatory, vascular, and cognitive endpoints for drug and biomarker discovery in menopause-linked disease

• TuVivo-Nephro: Human-derived kidney organoids

iPSC-derived organoids form renal tubule and glomerulus structures; when engrafted under the mouse renal capsule they vascularize, develop full nephron architecture, and can be harvested for ex vivo or single-cell analyses—providing a versatile system for nephrogenesis, RAS-driven fibrosis, drug screening, and disease modeling